MUTATION OF HYDROPHOBIC RESIDUES IN THE C-TERMINAL DOMAIN OF THE MARBURG VIRUS MATRIX PROTEIN VP40 DISRUPTS TRAFFICKING TO THE PLASMA MEMBRANE

Mutation of Hydrophobic Residues in the C-Terminal Domain of the Marburg Virus Matrix Protein VP40 Disrupts Trafficking to the Plasma Membrane

Marburg virus (MARV) is a lipid-enveloped negative sense single stranded RNA virus, which can cause a deadly hemorrhagic fever.MARV encodes seven proteins, including VP40 (mVP40), a matrix protein that interacts with the cytoplasmic leaflet of the host cell plasma membrane.VP40 traffics to the plasma membrane inner leaflet, where it assembles to fa

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Proposed Design Philosophy for Seismic-Resistant Buildings

Modern seismic design and technologies have undergone tremendous developments.In SHIRTS URBAN SHORT SLV modern design codes, building structures subjected to high earthquake loads are allowed to experience plastic deformations without collapsing, and the design is permitted up to the ultimate strength.According to comparative results in Japan, the

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NEAR-DEATH EXPERIENCES BETWEEN SCIENCE AND PREJUDICE

Science exists to refute dogmas; nevertheless, dogmas may be introduced when undemonstrated scientific axioms lead us to reject facts incompatible with them.Several studies have proposed psychobiological interpretations of near-death experiences (NDEs), claiming that NDEs are a byproduct of brain functions gone awry; however, relevant facts incompa

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